UCN3

Across TCGA pan-cancer cohorts, UCN3 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of UCN3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UCN3 RNA is repressed in tumor relative to normal tissue. In most cancer types UCN3 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and LUSC are the cancer types where UCN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UCN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.943	<.001	10	view →
KICH	All	II,III,IV	−0.989	<.001	8	view →
LUSC	Female	All	−1.438	<.001	7	view →
READ	All	All	−2.312	.002	4	view →
THCA	All	All	−0.026	.001	3	view →
LUAD	All	All	−0.655	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

UCN3–COAD

Open the COAD breakdown →