UCN2

Across TCGA patient cohorts, UCN2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. COAD shows the largest number of these associations.

The most reproducible UCN2-associated genes across cancer lineages are RNU6-235P, RNU6-501P, and RNU4-24P. Each is linked with UCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCN2-to-partner and partner-to-UCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-235P grouped by UCN2-low versus UCN2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCN2→partner) and Y-score (partner→UCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-235P →	+0.334	+5.122	<.001	.004	3	1
COAD	RNU6-501P →	+0.358	+4.602	.003	.008	3	1
COAD	RNU4-24P →	+1.160	+4.681	<.001	.003	3	1
COAD	H2AC18 →	+0.247	+4.415	<.001	.006	3	1
COAD	RNU2-36P →	+1.534	+4.602	<.001	.008	3	1
COAD	YBX1P8 →	+0.238	+4.577	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RNU6-235P by UCN2 expression — COAD

Explore this box plot interactively →