UCK2

Across TCGA pan-cancer cohorts, UCK2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UCK2 data layer compared with 31 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UCK2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UCK2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where UCK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.760	0.935	.001	42	view →
CCRCC	DFS	Median	III,IV	0.105	0.904	.008	36	view →
UCEC	OS	Median	All	0.983	0.855	.015	12	view →
LUAD	OS	Median	II,III,IV	0.339	0.906	.004	6	view →
LSCC	DFS	Median	III,IV	0.601	0.988	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UCK2–HNSC (OS)

Open the HNSC breakdown →