UCK1

Across TCGA pan-cancer cohorts, UCK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UCK1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UCK1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UCK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where UCK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.600	0.815	.005	37	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	16	view →
PDAC	OS	Tertile	All	0.919	0.780	.018	13	view →
GBM	DFS	Median	All	0.566	0.785	.011	4	view →
UCEC	DFS	Median	All	1.000	0.948	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UCK1–HNSC (OS)

Open the HNSC breakdown →