UCK1

Across TCGA patient cohorts, UCK1 mutation is significantly associated with the RNA expression of many other genes, with 286 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCK1-associated genes across cancer lineages are RN7SKP59, RARRES2P9, and GPR180. Each is linked with UCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCK1-to-partner and partner-to-UCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP59 grouped by UCK1-low versus UCK1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCK1→partner) and Y-score (partner→UCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP59 →	+0.176	+6.618	<.001	.001	3	2
SKCM	RARRES2P9 →	+0.354	+4.118	<.001	.004	3	2
UCEC	GPR180 →	+0.569	+2.609	.001	.006	3	1
UCEC	RAD17 →	+0.443	+2.807	.009	.003	3	1
UCEC	DCK →	+0.784	+3.459	.002	.005	3	1
UCEC	WHAMM →	+0.529	+2.649	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 286 associations by consensus.

RN7SKP59 by UCK1 expression — BLCA

Explore this box plot interactively →