UCHL5

Across TCGA patient cohorts, UCHL5 mutation is significantly associated with the RNA expression of many other genes, with 1,568 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCHL5-associated genes across cancer lineages are RNA5SP113, RNA5SP72, and RNA5SP24. Each is linked with UCHL5 in more than 3 cancer types. Because this analysis shows association rather than direction, both UCHL5-to-partner and partner-to-UCHL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP113 grouped by UCHL5-low versus UCHL5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCHL5→partner) and Y-score (partner→UCHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP113 →	+0.474	+5.033	<.001	.003	3	4
UCEC	RNA5SP72 →	+0.201	+2.105	.001	.008	3	3
UCEC	RNA5SP24 →	+0.483	+1.976	<.001	.007	3	3
HNSC	SEPTIN14P19 →	+0.069	+5.822	<.001	.003	3	2
BLCA	RN7SKP270 →	+0.098	+6.048	<.001	<.001	3	2
BLCA	RPS29P31 →	+0.312	+5.255	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,568 associations by consensus.

RNA5SP113 by UCHL5 expression — BLCA

Explore this box plot interactively →