UCHL5

Across TCGA patient cohorts, UCHL5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCHL5-associated genes across cancer lineages are PCNA, EGFR_pY1068, and A-Raf_pS299. Each is linked with UCHL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCHL5-to-partner and partner-to-UCHL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by UCHL5-low versus UCHL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCHL5→partner) and Y-score (partner→UCHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.277	+3.700	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.309	-2.087	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.151	-3.169	<.001	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.490	+2.331	.011	.019	3	1
UCEC	JNK2 →	+0.254	+2.009	<.001	.017	3	1
UCEC	Ku80 →	+0.182	+1.335	.044	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PCNA by UCHL5 expression — UCEC

Explore this box plot interactively →