UCHL3

Across TCGA pan-cancer cohorts, UCHL3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UCHL3 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UCHL3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UCHL3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where UCHL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.982	0.751	<.001	24	view →
PDAC	DFS	Quartile	II,III,IV	0.473	0.286	.019	6	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	5	view →
GBM	DFS	Tertile	All	0.526	0.828	.017	4	view →
LSCC	OS	Quartile	All	0.687	0.918	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UCHL3–UCEC (DFS)

Open the UCEC breakdown →