UCHL1

Across TCGA pan-cancer cohorts, UCHL1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UCHL1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UCHL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UCHL1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where UCHL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.189	0.889	.001	70	view →
LUAD	OS	Median	All	0.644	0.880	.003	9	view →
UCEC	DFS	Tertile	All	0.779	0.951	.021	8	view →
PDAC	OS	Median	III,IV	0.788	0.389	.026	6	view →
GBM	DFS	Quartile	All	0.840	0.560	.018	4	view →
HNSC	DFS	Median	III,IV	1.000	0.937	.035	3	view →
LSCC	DFS	Tertile	All	0.510	0.877	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UCHL1–CCRCC (DFS)

Open the CCRCC breakdown →