UCHL1

Across TCGA patient cohorts, UCHL1 mutation is significantly associated with the RNA expression of many other genes, with 566 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCHL1-associated genes across cancer lineages are RPL7P34, MIR147A, and MIR3691. Each is linked with UCHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCHL1-to-partner and partner-to-UCHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7P34 grouped by UCHL1-low versus UCHL1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCHL1→partner) and Y-score (partner→UCHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RPL7P34 →	+0.069	+5.758	<.001	.003	3	2
COAD	MIR147A →	+0.486	+4.893	.001	.005	3	2
LUAD	MIR3691 →	+0.485	+4.926	.007	.002	3	2
BLCA	RN7SL577P →	+0.199	+4.299	.009	.007	3	2
SKCM	AQP7P4 →	+0.064	+3.744	<.001	.003	3	2
SKCM	LINC02272 →	+0.051	+4.302	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 566 associations by consensus.

RPL7P34 by UCHL1 expression — LIHC

Explore this box plot interactively →