UCHL1

Across TCGA patient cohorts, UCHL1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCHL1-associated genes across cancer lineages are ERK2, MAPK_pT202_Y204, and MEK1_p_S217_S221. Each is linked with UCHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCHL1-to-partner and partner-to-UCHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by UCHL1-low versus UCHL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCHL1→partner) and Y-score (partner→UCHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.251	+3.000	.009	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.567	-2.321	.016	.035	3	1
UCEC	MEK1_p_S217_S221 →	-0.272	-2.321	.047	.035	3	1
UCEC	PI3K-p85 →	+0.313	+2.321	.002	.035	3	1
UCEC	Rictor_pT1135 →	-0.122	-3.459	.018	.005	3	1
UCEC	Src_pY416 →	-0.239	-2.308	.048	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ERK2 by UCHL1 expression — UCEC

Explore this box plot interactively →