UBXN8

Across TCGA patient cohorts, UBXN8 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBXN8-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with UBXN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBXN8-to-partner and partner-to-UBXN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UBXN8-low versus UBXN8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBXN8→partner) and Y-score (partner→UBXN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.290	-3.584	.016	.002	3	1
UCEC	A-Raf_pS299 →	-0.189	-3.000	.001	.036	3	1
UCEC	ERK2 →	+0.302	+3.321	.001	.010	3	1
UCEC	Ku80 →	+0.253	+2.472	.026	.011	3	1
UCEC	Myosin-IIa_pS1943 →	+0.206	+2.472	.038	.011	3	1
UCEC	PCNA →	+0.297	+2.459	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by UBXN8 expression — UCEC

Explore this box plot interactively →