UBXN7

Across TCGA patient cohorts, UBXN7 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBXN7-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eEF2. Each is linked with UBXN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBXN7-to-partner and partner-to-UBXN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UBXN7-low versus UBXN7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBXN7→partner) and Y-score (partner→UBXN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.526	-1.514	<.001	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.635	+2.019	.001	.005	3	2
UCEC	eEF2 →	+0.255	+1.874	.036	.049	3	1
UCEC	EGFR_pY1068 →	-0.322	-3.906	<.001	<.001	3	1
UCEC	eIF4E →	+0.159	+2.598	.026	.005	3	1
UCEC	A-Raf_pS299 →	-0.138	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by UBXN7 expression — UCEC

Explore this box plot interactively →