UBXN4

Across TCGA pan-cancer cohorts, UBXN4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBXN4 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UBXN4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBXN4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where UBXN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.569	1.000	.011	12	view →
LSCC	OS	Median	All	1.000	0.937	.012	9	view →
HNSC	DFS	Median	III,IV	0.905	0.993	.024	8	view →
LUAD	OS	Median	III,IV	0.229	0.620	.036	4	view →
GBM	DFS	Median	All	0.458	0.295	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBXN4–CCRCC (OS)

Open the CCRCC breakdown →