UBXN4

Across TCGA patient cohorts, UBXN4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBXN4-associated genes across cancer lineages are ATM, GAPDH, and INPP4B. Each is linked with UBXN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBXN4-to-partner and partner-to-UBXN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UBXN4-low versus UBXN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBXN4→partner) and Y-score (partner→UBXN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.592	-3.169	.003	.019	3	3
UCEC	GAPDH →	+0.517	+2.999	.032	.035	3	2
UCEC	INPP4B →	-0.329	-2.321	.024	.034	3	2
UCEC	Gab2 →	+0.331	+2.000	.039	.032	3	1
UCEC	MEK1 →	+0.496	+3.321	.002	.010	3	1
UCEC	p62 Lck ligand →	+0.384	+3.331	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by UBXN4 expression — UCEC

Explore this box plot interactively →