Across TCGA pan-cancer cohorts, UBXN2B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBXN2B data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBXN2B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBXN2B expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where UBXN2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	8	view →
GBM	OS	Quartile	All	0.929	0.742	.011	7	view →
CCRCC	OS	Median	All	0.911	1.000	.023	5	view →
LSCC	OS	Median	All	0.938	0.809	.017	3	view →
PDAC	DFS	Median	IV	0.182	0.515	.024	3	view →
LUAD	OS	Tertile	All	0.911	0.709	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: UBXN2B tumor-vs-normal RNA expression · all UBXN2B data types