UBXN11

Across TCGA patient cohorts, UBXN11 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBXN11-associated genes across cancer lineages are Notch1, 4E-BP1, and ERK2. Each is linked with UBXN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBXN11-to-partner and partner-to-UBXN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by UBXN11-low versus UBXN11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBXN11→partner) and Y-score (partner→UBXN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.220	+3.000	<.001	.001	3	2
UCEC	4E-BP1 →	+0.255	+2.351	.022	.018	3	2
UCEC	ERK2 →	+0.226	+3.321	.004	.009	3	1
UCEC	Gab2 →	+0.375	+2.321	.010	.006	3	1
UCEC	JNK2 →	+0.226	+1.807	.005	.027	3	1
UCEC	MEK1 →	+0.532	+3.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Notch1 by UBXN11 expression — UCEC

Explore this box plot interactively →