UBTF

Across TCGA pan-cancer cohorts, UBTF mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBTF data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UBTF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UBTF expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and HNSC are the cancer types where UBTF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.886	.020	54	view →
LSCC	DFS	Median	II,III,IV	0.890	0.464	<.001	35	view →
HNSC	OS	Median	All	0.789	0.897	.014	13	view →
GBM	OS	Quartile	All	0.595	0.243	.002	8	view →
UCEC	DFS	Quartile	All	0.883	1.000	.024	6	view →
CCRCC	DFS	Quartile	III,IV	0.773	0.419	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBTF–COAD (DFS)

Open the COAD breakdown →