UBR7

Across TCGA pan-cancer cohorts, UBR7 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBR7 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBR7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBR7 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where UBR7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.185	0.810	.006	34	view →
PDAC	DFS	Tertile	All	0.517	0.285	.001	24	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.605	.007	15	view →
CCRCC	DFS	Tertile	III,IV	0.904	0.125	.024	13	view →
LUAD	DFS	Quartile	II,III,IV	0.705	0.379	.016	7	view →
UCEC	DFS	Median	II,III,IV	0.880	0.521	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBR7–HNSC (DFS)

Open the HNSC breakdown →