UBR5

Across TCGA pan-cancer cohorts, UBR5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UBR5 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher UBR5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UBR5 expression acts as an unfavorable survival marker, although some lineages such as OV and GBM show a favorable association.

OV, GBM, and PDAC are the cancer types where UBR5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	1.000	0.648	.011	8	view →
GBM	OS	Quartile	All	0.960	0.528	.013	5	view →
PDAC	DFS	Median	All	0.723	0.859	.024	4	view →
LUAD	OS	Median	III,IV	0.702	0.233	.030	4	view →
CCRCC	DFS	Median	III,IV	0.558	0.789	.021	3	view →
HNSC	OS	Tertile	All	0.818	0.941	.021	3	view →
LSCC	DFS	Quartile	All	0.953	0.877	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UBR5–OV (DFS)

Open the OV breakdown →