UBR5

Across TCGA patient cohorts, UBR5 protein abundance is significantly associated with the RNA expression of many other genes, with 17,262 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible UBR5-associated genes across cancer lineages are MYBL2, UBE2C, and ORC6. Each is linked with UBR5 in more than 8 cancer types. Because this analysis shows association rather than direction, both UBR5-to-partner and partner-to-UBR5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UBR5 versus MYBL2 in BRCA, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR5→partner) and Y-score (partner→UBR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYBL2 →	+1.656	+0.283	<.001	<.001	3	9
LUAD	UBE2C →	+1.333	+0.172	<.001	<.001	3	9
GBM	ORC6 →	+0.989	+0.216	<.001	<.001	3	9
UCEC	GINS1 →	+0.960	+0.175	<.001	<.001	3	8
UCEC	MCM4 →	+0.868	+0.190	<.001	<.001	3	8
UCEC	NCAPG →	+0.830	+0.159	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,262 associations by consensus.

UBR5 vs MYBL2 — BRCA

Explore this scatter interactively →