UBR5

Across TCGA patient cohorts, UBR5 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBR5-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-E2, and ASNS. Each is linked with UBR5 in more than 4 cancer types. Because this analysis shows association rather than direction, both UBR5-to-partner and partner-to-UBR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by UBR5-low versus UBR5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR5→partner) and Y-score (partner→UBR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.581	+3.178	<.001	.010	3	5
STAD	Cyclin-E2 →	+0.224	+3.169	<.001	.018	3	4
STAD	ASNS →	+0.532	+3.321	.010	.009	3	3
UCEC	MEK1 →	+0.401	+1.750	<.001	<.001	3	3
SKCM	TIGAR →	+0.100	+1.749	.048	.049	3	3
UCEC	PDCD4 →	-0.288	-1.000	.019	.020	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Caspase-7-cleavedD198 by UBR5 expression — COAD

Explore this box plot interactively →