UBR5

Across TCGA cell cohorts, UBR5 mutation is significantly associated with the RNA expression of many other genes, with 2,438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBR5-associated genes across cancer lineages are F11, CCT8L2, and RHBDD3. Each is linked with UBR5 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBR5-to-partner and partner-to-UBR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F11 grouped by UBR5-low versus UBR5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR5→partner) and Y-score (partner→UBR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	F11 →	+0.089	+3.177	<.001	.004	3	3
SKIN	CCT8L2 →	+0.043	+4.022	<.001	.006	3	3
LARGE_INTESTINE	RHBDD3 →	+0.666	+2.130	.004	<.001	3	3
LARGE_INTESTINE	CLUAP1 →	+0.465	+2.000	.007	.009	3	3
LARGE_INTESTINE	GPR63 →	+0.815	+2.000	<.001	<.001	3	3
LARGE_INTESTINE	SLC35A1 →	+0.787	+2.130	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,438 associations by consensus.

F11 by UBR5 expression — BLOOD_Leukemia

Explore this box plot interactively →