UBR5

Across TCGA cell cohorts, UBR5 mutation is significantly associated with the mutation status of many other genes, with 6,213 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBR5-associated genes across cancer lineages are HECW2, KCNMA1, and SLC38A10. Each is linked with UBR5 in more than 5 cancer types. Because this analysis shows association rather than direction, both UBR5-to-partner and partner-to-UBR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HECW2 grouped by UBR5-low versus UBR5-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR5→partner) and Y-score (partner→UBR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HECW2 →	+5.000	+4.437	.007	.007	1	6
CNS	KCNMA1 →	+5.277	+4.459	.005	.005	1	6
CNS	SLC38A10 →	+5.277	+4.459	.005	.005	1	6
BLOOD_Lymphoma	SPEG →	+3.409	+3.752	<.001	<.001	1	6
LARGE_INTESTINE	SCN4A →	+2.091	+1.710	<.001	<.001	1	6
LARGE_INTESTINE	KDM4B →	+3.091	+2.051	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,213 associations by consensus.

HECW2 by UBR5 expression — BONE

Explore this box plot interactively →