UBR4

Across TCGA patient cohorts, UBR4 mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. COAD shows the largest number of these associations.

The most reproducible UBR4-associated genes across cancer lineages are Cyclin-E2, PRDX1, and TFRC. Each is linked with UBR4 in more than 4 cancer types. Because this analysis shows association rather than direction, both UBR4-to-partner and partner-to-UBR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by UBR4-low versus UBR4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR4→partner) and Y-score (partner→UBR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.189	+2.195	.008	.001	3	5
SKCM	PRDX1 →	+0.251	+1.321	.010	.028	3	4
LUAD	TFRC →	+0.412	+3.169	.036	.018	3	4
COAD	Caspase-7-cleavedD198 →	+1.337	+3.186	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.294	+1.232	<.001	<.001	3	4
COAD	NF-kB-p65_pS536 →	-0.501	-2.074	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

Cyclin-E2 by UBR4 expression — COAD

Explore this box plot interactively →