UBR4

Across TCGA cell cohorts, UBR4 mutation is significantly associated with the RNA expression of many other genes, with 1,960 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBR4-associated genes across cancer lineages are ADNP2, ATP1A3, and RLF. Each is linked with UBR4 in more than 3 cancer types. Because this analysis shows association rather than direction, both UBR4-to-partner and partner-to-UBR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADNP2 grouped by UBR4-low versus UBR4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR4→partner) and Y-score (partner→UBR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADNP2 →	+0.738	+2.700	<.001	<.001	3	3
BLOOD_Leukemia	ATP1A3 →	+1.723	+3.351	.007	.003	3	3
LARGE_INTESTINE	RLF →	+0.521	+1.628	<.001	<.001	3	3
LARGE_INTESTINE	ACYP1 →	+0.385	+1.807	.008	.005	3	3
BLOOD_Leukemia	MAP3K10 →	+0.792	+3.411	.002	.003	3	3
LARGE_INTESTINE	USP37 →	+0.559	+1.742	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,960 associations by consensus.

ADNP2 by UBR4 expression — LARGE_INTESTINE

Explore this box plot interactively →