UBR2

Across TCGA pan-cancer cohorts, UBR2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UBR2 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UBR2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UBR2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where UBR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.889	0.496	<.001	27	view →
PDAC	OS	Median	All	0.360	0.602	.001	10	view →
UCEC	OS	Median	II,III,IV	1.000	0.628	.013	4	view →
CCRCC	OS	Tertile	All	0.667	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UBR2–LSCC (DFS)

Open the LSCC breakdown →