UBR2

Across TCGA pan-cancer cohorts, UBR2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of UBR2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBR2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UBR2 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where UBR2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBR2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.194	<.001	11	view →
LUAD	Female	All	+0.148	<.001	8	view →
PDAC	All	All	−0.243	<.001	6	view →
LSCC	All	All	+0.059	.005	4	view →
OV	All	All	+0.197	.024	2	view →
CCRCC	Male	IV	−0.137	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

UBR2–HNSC

Open the HNSC breakdown →