UBR2

Across TCGA patient cohorts, UBR2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBR2-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eIF4G. Each is linked with UBR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBR2-to-partner and partner-to-UBR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UBR2-low versus UBR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR2→partner) and Y-score (partner→UBR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.551	-1.947	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.980	+1.947	<.001	<.001	3	3
UCEC	eIF4G →	+0.201	+1.874	.034	.049	3	2
UCEC	ERK2 →	+0.159	+1.263	.006	.019	3	2
UCEC	p62 Lck ligand →	+0.426	+1.947	<.001	<.001	3	2
UCEC	PCNA →	+0.231	+2.222	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by UBR2 expression — UCEC

Explore this box plot interactively →