UBR2

Across TCGA cell cohorts, UBR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,441 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBR2-associated GO terms across cancer lineages are Ubiquitin-dependent protein catabolic process via the N-end rule pathway, Post-Golgi vesicle-mediated transport, and Establishment of protein localization to vacuole. Each is linked with UBR2 in more than 15 cancer types. Because this analysis shows association rather than direction, both UBR2-to-partner and partner-to-UBR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ubiquitin-dependent protein catabolic process via the N-end rule pathway grouped by UBR2-low versus UBR2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR2→partner) and Y-score (partner→UBR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.108	+0.686	<.001	.001	3	16
BONE	Post-Golgi vesicle-mediated transport →	+0.074	+0.517	.008	.001	3	15
STOMACH	Establishment of protein localization to vacuole →	+0.098	+0.741	<.001	<.001	3	14
STOMACH	Vesicle-mediated transport to the plasma membrane →	+0.086	+0.614	<.001	.002	3	14
STOMACH	Golgi to plasma membrane transport →	+0.092	+0.620	.005	.004	2	15
STOMACH	Endosomal transport →	+0.073	+0.701	<.001	.001	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,441 associations by consensus.

Ubiquitin-dependent protein catabolic process via the N-end rule pathway by UBR2 expression — STOMACH

Explore this box plot interactively →