UBR2

Across TCGA cell cohorts, UBR2 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBR2-associated genes across cancer lineages are H2BW2, MROH2B, and TEKT1. Each is linked with UBR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBR2-to-partner and partner-to-UBR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW2 grouped by UBR2-low versus UBR2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR2→partner) and Y-score (partner→UBR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	H2BW2 →	+0.240	+4.029	<.001	.007	3	3
BLOOD_Lymphoma	MROH2B →	+0.116	+5.643	<.001	.002	3	2
SKIN	TEKT1 →	+0.051	+3.930	.006	.003	3	2
SKIN	ADAM18 →	+0.078	+4.196	<.001	.002	3	2
PANCREAS	GZMK →	+0.004	+4.029	<.001	.007	3	1
PANCREAS	SLC7A3 →	+0.039	+3.736	<.001	.006	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

H2BW2 by UBR2 expression — PANCREAS

Explore this box plot interactively →