UBR1

Across TCGA pan-cancer cohorts, UBR1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UBR1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBR1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBR1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where UBR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.166	0.973	.010	61	view →
LSCC	DFS	Quartile	All	0.213	0.928	.001	29	view →
CCRCC	OS	Median	IV	0.451	1.000	.016	8	view →
LUAD	OS	Quartile	III,IV	0.819	0.265	.027	4	view →
UCEC	DFS	Median	All	0.920	0.785	.030	2	view →
GBM	OS	Median	All	0.393	0.644	.032	2	view →
PDAC	OS	Median	All	0.906	0.784	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UBR1–HNSC (OS)

Open the HNSC breakdown →