UBQLNL

Across TCGA patient cohorts, UBQLNL mutation is significantly associated with the RNA expression of many other genes, with 4,860 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBQLNL-associated genes across cancer lineages are BUB3, GPATCH4, and SPC24. Each is linked with UBQLNL in more than 2 cancer types. Because this analysis shows association rather than direction, both UBQLNL-to-partner and partner-to-UBQLNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by UBQLNL-low versus UBQLNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLNL→partner) and Y-score (partner→UBQLNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.540	+3.981	<.001	<.001	3	3
UCEC	GPATCH4 →	+0.440	+1.828	.007	.002	3	3
UCEC	SPC24 →	+0.625	+2.523	.002	<.001	3	3
UCEC	TEDC2 →	+0.768	+3.021	<.001	<.001	3	3
UCEC	TMEM183A →	+0.523	+2.513	<.001	<.001	3	3
UCEC	PBK →	+1.106	+3.010	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,860 associations by consensus.

BUB3 by UBQLNL expression — UCEC

Explore this box plot interactively →