UBQLNL

Across TCGA patient cohorts, UBQLNL mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBQLNL-associated genes across cancer lineages are GATA6, MEK1, and P-Cadherin. Each is linked with UBQLNL in more than 1 cancer types. Because this analysis shows association rather than direction, both UBQLNL-to-partner and partner-to-UBQLNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by UBQLNL-low versus UBQLNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLNL→partner) and Y-score (partner→UBQLNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.155	-2.321	.006	.005	3	2
UCEC	MEK1 →	+0.387	+2.169	.003	.003	3	2
UCEC	P-Cadherin →	-0.151	-3.584	.004	.002	3	2
UCEC	STAT3_pY705 →	-0.394	-1.847	<.001	.008	3	2
UCEC	ATM →	-0.457	-2.308	.006	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.566	+1.604	.009	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

GATA6 by UBQLNL expression — UCEC

Explore this box plot interactively →