UBQLNL

Across TCGA cell cohorts, UBQLNL mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBQLNL-associated genes across cancer lineages are PRM3, EN1, and C10orf53. Each is linked with UBQLNL in more than 1 cancer types. Because this analysis shows association rather than direction, both UBQLNL-to-partner and partner-to-UBQLNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM3 grouped by UBQLNL-low versus UBQLNL-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLNL→partner) and Y-score (partner→UBQLNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRM3 →	+0.178	+5.754	<.001	.002	3	1
LARGE_INTESTINE	EN1 →	+0.839	+3.536	.008	.003	3	1
LARGE_INTESTINE	C10orf53 →	+0.013	+3.217	<.001	.006	3	1
LARGE_INTESTINE	GLP2R →	+0.140	+3.706	<.001	.002	3	1
SKIN	OR6X1 →	+0.012	+3.700	<.001	.009	3	1
SKIN	PVALEF →	+0.060	+3.491	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PRM3 by UBQLNL expression — CNS

Explore this box plot interactively →