UBQLN4

Across TCGA pan-cancer cohorts, UBQLN4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UBQLN4 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UBQLN4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UBQLN4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where UBQLN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.598	.005	19	view →
CCRCC	DFS	Tertile	IV	0.212	1.000	.024	6	view →
PDAC	DFS	Median	III,IV	0.250	0.471	.015	5	view →
GBM	DFS	Quartile	All	0.517	0.305	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UBQLN4–LSCC (OS)

Open the LSCC breakdown →