UBQLN4

Across TCGA pan-cancer cohorts, UBQLN4 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of UBQLN4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UBQLN4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UBQLN4 is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where UBQLN4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBQLN4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.233	<.001	8	view →
LUAD	All	II,III,IV	+0.136	<.001	8	view →
LSCC	Male	All	+0.195	<.001	5	view →
PDAC	Female	III,IV	−0.238	.025	4	view →
HNSC	Male	All	−0.100	.013	4	view →
CCRCC	Male	All	+0.085	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

UBQLN4–COAD

Open the COAD breakdown →