UBQLN4

Across TCGA patient cohorts, UBQLN4 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBQLN4-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, MEK1, and MSH2. Each is linked with UBQLN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBQLN4-to-partner and partner-to-UBQLN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by UBQLN4-low versus UBQLN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLN4→partner) and Y-score (partner→UBQLN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.518	+2.000	.023	.032	3	1
UCEC	MEK1 →	+0.465	+2.700	.004	.006	3	1
UCEC	MSH2 →	-0.329	-2.973	.001	.035	3	1
UCEC	MSH6 →	-0.439	-2.999	.003	.035	3	1
UCEC	mTOR →	-0.206	-2.700	.004	.006	3	1
UCEC	Notch1 →	+0.127	+3.013	.044	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Acetyl-a-Tubulin-Lys40 by UBQLN4 expression — UCEC

Explore this box plot interactively →