Across TCGA pan-cancer cohorts, UBQLN2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBQLN2 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UBQLN2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBQLN2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where UBQLN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.527	0.906	<.001	30	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	10	view →
PDAC	OS	Median	III,IV	0.537	1.000	.008	7	view →
LUAD	OS	Quartile	II,III,IV	0.227	0.783	.047	2	view →
HNSC	OS	Median	II,III,IV	0.804	0.654	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: UBQLN2 tumor-vs-normal RNA expression · all UBQLN2 data types