UBQLN2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, UBQLN2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBQLN2-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and p62 Lck ligand. Each is linked with UBQLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBQLN2-to-partner and partner-to-UBQLN2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBQLN2→partner) and Y-score (partner→UBQLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECNotch1 →+0.155+2.369<.001<.00132
UCECp38-MAPK_pT180_Y182 →-0.262-1.514.048.01432
UCECp62 Lck ligand →+0.341+2.009<.001.00132
UCECCyclin-B1 →+0.731+2.736<.001<.00132
UCECCyclin-E2 →+0.103+1.241.037.01532
UCECEGFR_pY1068 →-0.170-1.415.021.04031
Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration