UBQLN1

Across TCGA pan-cancer cohorts, UBQLN1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UBQLN1 data layer compared with 16 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBQLN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UBQLN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where UBQLN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.991	0.889	.002	26	view →
UCEC	DFS	Quartile	III,IV	1.000	0.280	.008	12	view →
PDAC	OS	Quartile	II,III,IV	0.493	0.895	.015	11	view →
LSCC	OS	Median	All	0.807	0.935	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UBQLN1–HNSC (DFS)

Open the HNSC breakdown →