UBN2

Across TCGA patient cohorts, UBN2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBN2-associated genes across cancer lineages are FoxM1, PRAS40_pT246, and EGFR_pY1068. Each is linked with UBN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBN2-to-partner and partner-to-UBN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by UBN2-low versus UBN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBN2→partner) and Y-score (partner→UBN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.194	+1.765	.045	.014	3	3
UCEC	PRAS40_pT246 →	+0.137	+1.428	.034	.029	3	3
UCEC	EGFR_pY1068 →	-0.236	-2.807	.012	.003	3	2
UCEC	Gab2 →	+0.289	+1.415	.030	.046	3	2
UCEC	PDCD4 →	-0.459	-1.415	.009	.046	3	2
UCEC	AR →	-0.340	-1.415	.015	.046	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FoxM1 by UBN2 expression — UCEC

Explore this box plot interactively →