UBN1

Across TCGA patient cohorts, UBN1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBN1-associated genes across cancer lineages are Cyclin-B1, PCNA, and p38-MAPK_pT180_Y182. Each is linked with UBN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBN1-to-partner and partner-to-UBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by UBN1-low versus UBN1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBN1→partner) and Y-score (partner→UBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Cyclin-B1 →	+0.685	+3.000	.006	.036	3	3
UCEC	PCNA →	+0.224	+2.000	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.366	-1.334	.004	.006	3	2
UCEC	TFRC →	+0.442	+2.247	.003	.001	3	2
UCEC	ASNS →	+0.262	+1.847	.011	.007	3	2
UCEC	Cyclin-E2 →	+0.129	+1.299	.007	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Cyclin-B1 by UBN1 expression — BLCA

Explore this box plot interactively →