UBE4B

Across TCGA cell cohorts, UBE4B mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE4B-associated genes across cancer lineages are GJA10, GZMK, and FFAR3. Each is linked with UBE4B in more than 2 cancer types. Because this analysis shows association rather than direction, both UBE4B-to-partner and partner-to-UBE4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA10 grouped by UBE4B-low versus UBE4B-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE4B→partner) and Y-score (partner→UBE4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GJA10 →	+0.263	+4.786	<.001	.001	3	3
PANCREAS	GZMK →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	FFAR3 →	+0.028	+4.237	.009	.006	3	1
PANCREAS	NCR1 →	+0.029	+4.786	<.001	.001	3	1
PANCREAS	TP53TG3B →	+0.322	+4.011	<.001	.009	3	1
OESOPHAGUS	OR2M3 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

GJA10 by UBE4B expression — PANCREAS

Explore this box plot interactively →