UBE4A

Across TCGA pan-cancer cohorts, UBE4A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UBE4A data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher UBE4A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UBE4A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, UCEC, and CESC are the cancer types where UBE4A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.082	0.653	.002	15	view →
UCEC	DFS	Median	II,III,IV	0.896	0.429	.015	12	view →
CESC	OS	Median	II,III,IV	0.227	0.759	.029	6	view →
SKCM	DFS	Median	II,III,IV	0.192	0.707	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UBE4A–SCLC (OS)

Open the SCLC breakdown →