UBE4A

Across TCGA pan-cancer cohorts, UBE4A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of UBE4A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where UBE4A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types UBE4A is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and PDAC are the cancer types where UBE4A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE4A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	−0.097	<.001	7	view →
COAD	All	All	−0.080	<.001	7	view →
PDAC	Male	All	+0.274	.002	6	view →
LSCC	All	All	−0.097	<.001	5	view →
LUAD	All	All	+0.086	<.001	5	view →
HNSC	All	IV	−0.133	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

UBE4A–CCRCC

Open the CCRCC breakdown →