UBE4A

Across TCGA patient cohorts, UBE4A mutation is significantly associated with the RNA expression of many other genes, with 4,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE4A-associated genes across cancer lineages are ATP5F1C, RNU4-9P, and RNU6-24P. Each is linked with UBE4A in more than 2 cancer types. Because this analysis shows association rather than direction, both UBE4A-to-partner and partner-to-UBE4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1C grouped by UBE4A-low versus UBE4A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE4A→partner) and Y-score (partner→UBE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATP5F1C →	+0.444	+2.610	.004	.005	3	3
HNSC	RNU4-9P →	+0.166	+3.566	.002	.004	3	2
HNSC	RNU6-24P →	+0.293	+3.226	<.001	.009	3	2
HNSC	MIR1265 →	+0.143	+5.363	<.001	.001	3	2
LUSC	RNA5SP413 →	+0.898	+6.666	<.001	<.001	3	2
LUSC	RNA5SP417 →	+0.677	+4.882	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,257 associations by consensus.

ATP5F1C by UBE4A expression — SKCM

Explore this box plot interactively →