UBE4A

Across TCGA patient cohorts, UBE4A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE4A-associated genes across cancer lineages are EGFR_pY1068, ERK2, and FoxM1. Each is linked with UBE4A in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE4A-to-partner and partner-to-UBE4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by UBE4A-low versus UBE4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE4A→partner) and Y-score (partner→UBE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.186	-1.523	.009	.006	3	2
UCEC	ERK2 →	+0.141	+1.584	.010	.001	3	2
UCEC	FoxM1 →	+0.182	+2.222	.013	.009	3	2
UCEC	Shc_pY317 →	-0.104	-1.222	.015	.011	3	2
UCEC	ATM →	-0.457	-1.584	<.001	.001	3	2
UCEC	c-Kit →	-0.165	-2.000	.012	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

EGFR_pY1068 by UBE4A expression — UCEC

Explore this box plot interactively →