UBE4A

Across TCGA cell cohorts, UBE4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,795 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBE4A-associated GO terms across cancer lineages are Meiotic chromosome condensation, Cell cycle checkpoint signaling, and Positive regulation of TORC2 signaling. Each is linked with UBE4A in more than 14 cancer types. Because this analysis shows association rather than direction, both UBE4A-to-partner and partner-to-UBE4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic chromosome condensation grouped by UBE4A-low versus UBE4A-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE4A→partner) and Y-score (partner→UBE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Meiotic chromosome condensation →	+0.213	+0.886	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.093	+1.207	.001	<.001	3	15
STOMACH	Positive regulation of TORC2 signaling →	+0.123	+0.724	.002	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Signal transduction in response to DNA damage →	+0.075	+1.103	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.076	+1.032	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.086	+1.236	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,795 associations by consensus.

Meiotic chromosome condensation by UBE4A expression — SOFT_TISSUE

Explore this box plot interactively →