UBE4A

Across TCGA cell cohorts, UBE4A mutation is significantly associated with the RNA expression of many other genes, with 294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE4A-associated genes across cancer lineages are RNF167, ENO2, and ARL6. Each is linked with UBE4A in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE4A-to-partner and partner-to-UBE4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF167 grouped by UBE4A-low versus UBE4A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE4A→partner) and Y-score (partner→UBE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNF167 →	+0.479	+3.212	.003	.006	3	2
LARGE_INTESTINE	ENO2 →	+1.586	+3.237	.001	.003	3	2
LARGE_INTESTINE	ARL6 →	+0.648	+3.064	<.001	.009	3	2
LARGE_INTESTINE	SLC25A51 →	+0.671	+3.212	<.001	.006	3	2
LARGE_INTESTINE	TTI2 →	+0.586	+3.212	.008	.006	3	2
LARGE_INTESTINE	GPR3 →	+1.072	+3.180	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

RNF167 by UBE4A expression — LARGE_INTESTINE

Explore this box plot interactively →